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Locally Advanced Where breast

Some are neglected primaries that have slowly progressed to an advanced stage whereas others result from rapid disease growth as a result of an aggressive biology. In contrast, locally advanced breast cancers diagnosed between screening intervals or shortly after the first sign or symptom of the disease commonly have high-grade and high-proliferative indices. Inflammatory breast cancer is the most aggressive subgroup of locally advanced breast cancer presenting with rapid disease growth and involvement of the dermal lymphatics. Inflammatory breast cancer has a high propensity for metastatic spread and carries a relatively poor prognosis. Locally advanced breast cancer LABC is a term that encompasses breast cancer that is inoperable or is operable only by mastectomy at initial presentation.

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